- Genetic causes of cancer
 Under construction.
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The genes and proteins that have been implicated in cancer. Includes both
tumor suppressors and oncogenes.
 p53. Tumor suppressor. Mutations in p53 are found in close to
50% of human cancers, including skin, colon, breast, liver, and lung.
- What is p53? From
the International Agency for Research on
Cancer comes this description of the canonical tumor suppressor p53,
which has been found mutated in so many different tumor types.
- Web
review for p53. p53 web resources are reviewed by HotMolecBase.
Other useful information on p53 structure, expression, and involvement
in disease are also provided.
- Rb. Tumor suppressor.
- BRCA1. Tumor suppressor. Mutations in this gene can predispose
to breast and ovarian cancer. A heterozygous woman (containing one good
copy of BRCA1 and one defective copy) has an 80% chance of developing breast
cancer during her life.
- Web
review for BRCA1. From HotMolecBase.
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This page was last updated on September 17, 1997.
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